Biography

Following his PhD in biochemistry from the Biozentrum of the University of Basel and postdoctoral work at Yale University School of Medicine Volker Haucke established his own laboratory at the University of Göttingen. He was appointed as a full professor of biochemistry at the Freie Universiät Berlin in 2003. Since 2012 he is director at the Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP), professor of molecular pharmacology at Freie Universität Berlin and a member of the NeuroCure Cluster of Excellence.

The focus of research in his laboratory is the dissection of the molecular mechanisms of endocytosis and endolysosomal membrane dynamics with a focus on the role of signaling lipids. The laboratory uses a wide range of technologies that include biochemical and cell biological approaches, electrophysiology, chemical biology, super-resolution and electron microscopy as well as genetic manipulations at the organismic level in vivo. His discoveries have provided insight into the roles of lipids in cell physiology and open new avenues for the treatment of human diseases ranging from cancer and thrombosis to neurological disorders. He was a Feldberg Prizewinner for 2020 who gave his lecture at University College London in September 2022.

Biography

Professor Dame Kay Davies, Ph.D., DBE FMedSci FRS is the Dr Lee’s Professor of Anatomy Emeritus and co-Director of the MDUK Oxford Neuromuscular Centre in the Department of Physiology, Anatomy and Genetics at the University of Oxford.  She received a BA degree in Chemistry and a graduate PhD degree in Biochemistry from the University of Oxford.  She was appointed Professor of Genetics in 1996 and then appointed Dr Lee’s Professor of Anatomy at the University of Oxford in 1998.  She was founding Director of the MRC Functional Genomics Unit 1999-2017 and co-founded the Oxford Centre of Gene Function in 2000 with Professors Ashcroft and Donnelly, a new institute going from genetic association in human disease to function in the whole organism. Kay’s research interests lie in the molecular analysis and development of treatments for genetic diseases, particularly Duchenne muscular dystrophy (DMD).  She has published more than 400 papers and won numerous awards for her work and co-founded companies to translate her work to the clinic.  Kay is a founding Fellow of the Academy of Medical Sciences and a Fellow of the Royal Society. She was appointed Governor of the Wellcome Trust in 2008 and became Deputy Chair 2013-17.   Until recently she chaired the Genome England Clinical Interpretation Partnership in the UK and is a member of the GRL Board at the Sanger Institute.  She was made Dame Commander of the British Empire for services to science in 2008.

Biography

Peter worked for the Medical Research Council in various roles both in Cambridge and London from 1970 until 2010.
He has been running the secretariat function of the Feldberg Foundation since 2002 and also became a Managing Trustee in 2012.

Biography

Gitta obtained her PhD in Biology at the University of Mainz and then did postdoctoral studies in London and Cambridge, followed by a postdoc at the Cancer Research Institute in Heidelberg. In 1985 she became a member of the Basel Institute for Immunology where she stayed until 1991.

In 1991 Gitta became a group leader in the Division of Molecular Immunology of the Medical Research Council National Institute for Medical Research (now part of the Francis Crick Institute) and Head of Division in 2010.

Her research interests over time included immune tolerance using T cell receptor transgenic mouse models and immunological memory focusing on CD4 memory T cells, their generation and survival.

Gitta’s lab got involved in infection and inflammation research following their discovery of the differentiation factors for Th17 generation. More recently they discovered the importance of the transcription factor aryl hydrocarbon receptor (AHR), an environmental sensor, in the immune system and beyond.

Gitta obtained an ERC Advanced Investigator grant in 2009 to study physiological functions of AHR and in 2013 was awarded a Wellcome Senior Investigator Grant to expand the investigation of AHR in innate and adaptive immune cells. She obtained a CRUK grant in 2015 to study the role of AHR in intestinal tumorigenesis and a Wellcome Investigator Grant in 2018 to focus on AHR influences in the intestinal environment.

She became a Fellow of the Academy of Medical Sciences in 2005, an EMBO fellow in 2008 and a Fellow of the Royal Society in 2013.

Biography

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Biography

We aim at understanding molecular mechanisms underlying chronic pain resulting from long-lasting inflammation or cancer. A major focus is laid on addressing signalling mechanisms which underlie activity-dependent changes in primary sensory neurons transmitting pain (nociceptors) and their synapses in the spinal dorsal horn. Our current work spans molecular, genetic, behavioural, electrophysiological and imaging approaches in vitro as well as in vivo in rodent models of pathological pain.

Biography

For the past 30 years Ed Hurt and his team members have conducted research on the structural and functional analysis of the yeast nuclear pore complex and the mechanism of nuclear transport. This work has also involved investigation of other cell machines, especially those that assemble and export mRNAs and ribosomal subunits.

Based on the genetic, biochemical and structural methods, we could dissect the yeast nuclear pore complex, followed by the identification and characterization of the primary nuclear mRNA export receptor and defining how it is coupled to transcription and chromatin modifying machineries. The other major research lead to the the dissection of the complicated biogenesis and export pathway of ribosomal subunits with identification of a series of ribosomal assembly mediates including their structural analysis by electron microscopy.

Overall this work has given insight into the structure and function of macromolecular machines that are composed of a large number of subunits and transiently interacting biogenesis factors.