Professor Veit Flockerzi

My laboratory focuses on the molecular processes underlying receptor-ion channel-coupling, particularly in heart and smooth muscle cells. Current studies seek to understand the role of specific transient receptor potential (TRP) channels in cellular excitation as well as the functions of β-subunits (CaVβ) of voltage-gated calcium channels which are independent of CaVα1, the ion conducting pore of these channels. Techniques used to study these processes include gene targeting, identification of novel genes through genomics screens, patch clamp measurements of ion channel function, Ca imaging, and protein biochemistry.

A major goal of the laboratory is to identify genes encoding channel proteins and relating signalling molecules involved in muscle biology and to determine their functions in health and disease. An additional effort in the laboratory is to combine genetics, protein chemistry and pharmacological procedures to advance the understanding of physiological processes.

Selected publications